New microscopy method for reference-free imaging of cellular forces published in Nature Cell Biology

Our work on Elastic Resonator Interference Stress Microscopy (ERISM) has just appeared in Nature Cell Biology. Congratulations to Nils Kronenberg, Philipp Liehm and all others who have developed and tested ERISM.

In contrast to existing methods, ERISM uses optical interference in a thin deformable substrate to map the force patterns created by cells. This provides exceptional resolution and robustness and avoids the need for zero-force reference measurements. Our paper describes several applications of ERISM, e.g. a study of podosomes in human macrophages and measurements of the weak forces involved in amoeboid migration.

Technical Reports are Nature Cell Biology’s format for “publishing the primary report on a new technique that is likely to be influential”.

The full study can be found here.

N.M. Kronenberg, P. Liehm, A. Steude, J.A. Knipper, J.G. Borger, G. Scarcelli, K.Franze, S.J. Powis, M.C. Gather, “Long-term imaging of cellular forces with high precision by elastic resonator interference stress microscopy”, Nature Cell Biology 10.1038/ncb3561 (2017).